劉威副研究員簡介
劉威,男,1985年出生,中共黨員,博士,副研究員,碩士研究生導師,約翰斯•霍普金斯大學訪問學者。農業農村部畜禽細菌病防治制劑創制重點實驗室、湖北省自然科學基金計劃創新群體核心成員。先後主持、承擔了國家自然科學基金、科技部重點研發計劃項目子課題等國家、省部級項目7項。獲國家一類新獸藥注冊證書1件;湖北省科技進步二等獎1項;授權國家發明專利11件;在Vaccines、Frontiers in Cellular and Infection Microbiology、Journal of Bacteriology、BMC Genomics、Microbial Pathogenesis、PLoS One 等SCI期刊發表論文21篇,在中國獸醫學報、動物醫學進展等期刊發表學術論文30餘篇。
研究方向:
1. 支原體、衣原體、緻腦膜炎性大腸杆菌等病原與宿主的相互作用及其免疫逃逸的分子機制研究;
2. 動物疫病快速診斷試劑研發;
3. 細菌基因工程疫苗的分子設計與創制。
代表性成果:
1. Wei Liu; Peizhao Jiang; Tao Song……et al; A Recombinant Chimera Vaccine Composed of LTB and Mycoplasma hyopneumoniae Antigens P97R1, mhp390 and P46 Elicits Cellular Immunologic Response in Mice, Vaccines, 2023, 11, 1291.
2. Wei Liu; Pengcheng Jiang; Keli Yang……et al; Mycoplasma hyopneumoniae Infection Activates the NOD1 Signaling Pathway to Modulate Inflammation. Frontiers in Cellular and Infection Microbiology, 2022, 12:927840.
3. Wei Liu; Danna Zhou; Fangyan Yuan……et al; Surface proteins mhp390 (P68) contributes to cilium adherence and mediates inflammation and apoptosis in Mycoplasma hyopneumoniae, Microbial Pathogenesis, 2019, 126: 92-100.
4. Wei Liu; Shaobo Xiao; Mao Li……et al; Comparative genomic analyses of Mycoplasma hyopneumoniae pathogenic 168 strain and its high-passaged attenuated strain, BMC Genomics, 2013, 14(80): 1-13.
5. Wei Liu; Liurong Fang; Mao Li……et al; Comparative genomics of Mycoplasma: analysis of conserved essential genes and diversity of the pan-genome, PLoS One, 2012, 7(4): e35698.
6. Wei Liu; Zhixin Feng; Liurong Fang……et al; Complete genome sequence of Mycoplasma hyopneumoniae strain 168, Journal of Bacteriology, 2011, 193(4): 1016-1017.
7. Wei Liu; Liurong Fang; Sha Li……et al; Complete Genome Sequence of Mycoplasma hyorhinis Strain HUB-1, Journal of Bacteriology, 2010, 192(21): 5844-5845.
在研項目:
1、企業橫向課題:畜用細菌與支原體培養基開發與研究,2022.12-2027.12,75萬元,主持。
2、湖北省預防獸醫學重點實驗室開放課題:膜脂蛋白 mhp390 在豬肺炎支原體感染與緻病中的作用研究,2023.01-2024.12,5萬元,主持。
聯系方式:電話:15527793518
郵箱:liuwei@hbaas.com